Which lipid can be used for pH dependent release features in liposomes?
The typical polymorphic lipid used to prepare pH-sensitive liposomes is the unsaturated phosphatidylethanolamine (PE), such as diacetylenic-phosphatidyl-ethanolamine (DAPE), palmitoyl-oleoyl-phosphatidyl-ethanolamine (POPE) and dioleoyl-phosphatidyl-ethanolamine (DOPE) .
Are liposomes acidic?
Generally, liposome is prepared in a neutral buffer solution and thus the loaded drug molecules are also in a neutral environment after incorporation into liposome.
What is liposomal formulation?
A liposome drug formulation is different from (1) an emulsion, which is a dispersed system of oil in water, or water in oil phases containing one or more surfactants, (2) a microemulsion, which is a thermodynamically stable two phase system containing oil or lipid, water and surfactants, and (3) a drug-lipid complex.
Are liposomes hydrophilic?
Liposomes can be defined as spherically shaped microscopic vesicles that consist of one or more phospholipid bilayer membranes. The general structure of liposomes is shown in Fig. 16.11. The inner core of liposomes consists of hydrophilic parts of the phospholipids, where hydrophilic molecules can be incorporated.
What is a pH sensitive liposome?
pH sensitive liposomes. or N-succinyl- DOPE. These lipids were neutral in nature in the acidic envi- membrane and release of their contents [ 2 ]. Different classes of pH sensitive liposomes are shown in Figure 6.2. in the first class. However, this class of pH sensitive liposomes is not often used for in vivo purposes.
What are the stabilizers of pH sensitive liposomes for membrane fusion?
The stabilizers of pH sensitive liposomes attained prota- ble for membrane fusion. In one study, the pH sensitive liposomes composed of DOPE and CHEMS. These liposomes reached the target site by endocytosis and released their contents, ultimately enhancing the cytosolic delivery [ 4 ].
What is the role of pH responsive liposomes in drug delivery?
It should be noted that pH responsive liposomes known significant therapy of viral infections, cancer or inflammatory diseases. Since liposomes as a carrier for their delivery. as endosomes, and facilitating the drug transit to the cytoplasm.
Can pH-sensitive liposomes be used to treat cancer?
Research focused on the clinical and therapeutic side of pH-sensitive liposomes would enable their commercial utility in cancer treatment. Antineoplastic Agents / administration & dosage*