What is uromitexan used for?
UROMITEXAN Injection is a protective agent which is used to prevent damage to your bladder and urinary system, that may be caused by some drugs used to treat cancer or auto-immune diseases. These drugs can cause a condition of the bladder, with pain in the bladder or back and blood in the urine.
What are the side effects of ifosfamide?
Common side effects
- Increased risk of getting an infection.
- Breathlessness and looking pale.
- Bruising, bleeding gums or nosebleeds.
- Tiredness and weakness (fatigue) during and after treatment.
- Feeling or being sick.
- Loss of appetite.
- Hair loss.
- Irritation of the bladder and kidneys.
Is mesna an irritant?
Why mesna is given. The chemotherapy drugs ifosfamide and cyclophosphamide can sometimes irritate the lining of the bladder. This can cause bleeding from the bladder and may show up as blood in your urine (pee). This is called haematuria.
Is mesna toxic?
Mesna in both oral and IV administrations is commonly associated with gastrointestinal side effects, including nausea, vomiting, constipation, abdominal pain, and bad taste.
What is ifosfamide toxicity?
Central nervous system (CNS) toxicity has been reported in approximately 10-30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and although usually transient and reversible, may cause persistent neurological dysfunction or death.
Which side effects of ifosfamide limit its use as anticancer agent?
Other toxicities include the following:
- Hemorrhagic Cystitis. Before the availability of mesna, the main adverse effect was hemorrhagic cystitis.
- Neurotoxicity.
- Hematologic Toxicity.
- Nephrotoxicity.
- Miscellaneous Toxicities.
- Malignancy of Ureter and Bladder.
What is mesna effect?
Mesna is used to reduce the risk of hemorrhagic cystitis (a condition that causes inflammation of the bladder and can result in serious bleeding) in people who receive ifosfamide (a medication used for the treatment of cancer). Mesna is in a class of medications called cytoprotectants.
Is mesna a chemotherapy drug?
Mesna is a drug given with some types of chemotherapy to help protect the bladder from irritation.
How do you treat ifosfamide neurotoxicity?
The recommended dose of intravenous MB for treatment of ifosfamide-induced encephalopathy is 50 mg every 4 hours (1% aqueous solution over 5 minutes), whereas the dose for secondary prophylaxis of ifosfamide-induced encephalopathy is 50 mg every 6 hours, either intravenously or orally [8].
Does ifosfamide cause myelosuppression?
5.1 Myelosuppression, Immunosuppression, and Infections Treatment with ifosfamide may cause myelosuppression and significant suppression of immune responses, which can lead to severe infections. Fatal outcomes of ifosfamide-associated myelosuppression have been reported.
How is ifosfamide neurotoxicity treated?
What is uromitexan?
Uromitexan is a sterile preservative-free aqueous solution of clear and colourless appearance in clear glass ampoules for intravenous administration. Mechanism of action.
Can uromitexan be used with oxazaphosphorine alkylating agents?
As Uromitexan is used in combination with oxazaphosphorine alkylating agents and other chemotherapeutic agents with documented toxicities, it is difficult to distinguish the adverse reactions which may be due to Uromitexan from those caused by the concomitantly administered cytotoxic agents.
How does uromitexan work in pulmonary function testing?
It acts by reducing the viscosity of pulmonary secretions; the drug’s free sulfhydryl group is thought to reduce disulfide linkages of mucoproteins. Uromitexan is a cytoprotective agent used as a prophylactic agent in reducing the incidence of ifosfamide-induced hemorrhagic cystitis.
How do you dilute uromitexan?
The drug can be diluted by adding the contents of a Uromitexan ampoule to any of the following fluids obtaining final concentrations of 1.5 to 3 mg mesna/mL fluid: lactated Ringer’s injection.