What does a high oil water partition coefficient mean?
Chemicals with high partition coefficients, for example, tend to accumulate in the fatty tissue of organisms (bioaccumulation). Under the Stockholm Convention, chemicals with a log Kow greater than 5 are considered to bioaccumulate.
What is the relation between partition and distribution coefficient?
The key difference between partition coefficient and distribution coefficient is that the partition coefficient refers to the concentration of un-ionized chemical species of a compound whereas the distribution coefficient refers to the concentration of both ionized and un-ionized chemical species of a compound.
What if partition coefficient is high?
It describes the partition of an agent between a gaseous phase, such as alveolar air, and the blood. The greater the blood:gas partition coefficient, the greater the solubility in blood. The oil:gas partition coefficient has been correlated to anesthetic potency – the higher the coefficient, the more potent the agent.
What does a partition coefficient greater than 1 mean?
The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is more soluble in water.
What should be the range of oil or water partition coefficient of any drug?
Q. | What should be the range of oil/water partition coefficient of any drug? |
---|---|
B. | 3-4 |
C. | 2-3 |
D. | 1-3 |
Answer» a. 1-2 |
How can partition coefficient be increased?
The partition coefficient can be altered by modifying the sample matrix. A common technique is the use of the salting-out effect. For aqueous samples with a high partition coefficient (e.g. ethanol in water), the addition of salt may enhance the sensitivity by up to a factor of 10.
What is the difference between solubility and partition coefficient?
The difference between the two is that solubility measures the amount of solute that can be dissolved in one solvent, while partition coefficient measures the ability of the solute to go into two immiscible phases.
What does it mean if the partition coefficient is greater than 1?
How does pH affect partition coefficient?
The study showed that both solubility and partition coefficient are pH-dependent, whereby solubility increases with increasing pH value above the pKa value, while partition coefficient decreases in the same conditions.
What are the factors affecting partition coefficient?
The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance. For example, the water solubility of hydroxyl, carboxyl, and amino groups reduces their solubility…