What are Streptogramins used to treat?
Streptogramins are mainly effective against gram-positive bacteria….They are mainly used for the treatment of:
- Skin infections.
- Bacteremia (presence of bacteria in the bloodstream)
- Intravascular catheter-associated bacteremia (catheter-related bloodstream infection)
What diseases macrolides treat?
Macrolides are the first choice of antibiotics to treat pneumonia, chlamydia, and urethritis. These antimicrobials are also known to have immunomodulatory benefits and anti-inflammatory properties, so they can treat other conditions rather than just bacteria infections.
What are the common side effects of macrolides?
Like any other antibiotic, macrolides carry a significant risk of typical adverse effects like nausea, vomiting, abdominal pain, and diarrhea. Abdominal symptoms are largely the result of macrolides being motilin agonists causing an increased risk of gastrointestinal upset and side effects.
What is linezolid good for?
Linezolid is used to treat infections, including pneumonia, and infections of the skin . Linezolid is in a class of antibacterials called oxazolidinones. It works by stopping the growth of bacteria.
What type of drug is pristinamycin IA?
Pristinamycin IA is a cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin -resistant Staphylococcus aureus.
What is the difference between Pi and pristinamycin IA?
Pristinamycin is a mixture of two components that have a synergistic antibacterial action. Pristinamycin IA is a macrolide, and results in pristinamycin’s having a similar spectrum of action to erythromycin. Pristinamycin IIA (streptogramin A) is a depsipeptide. PI and PII are coproduced by S. pristinaespiralis in a ratio of 30:70.
What is the mechanism of action of pristinamycin?
Pristinamycin exhibits bactericidal activity against Gram positive organisms including methicillin -resistant Staphylococcus aureus. It has a role as an antibacterial drug, an antimicrobial agent and a bacterial metabolite.
Can pristinamycin cause diarrhea in an 85-year-old woman?
An 85-year-old woman developed a severe illness (severe diarrhea and vomiting, abdominal tenderness, peritoneal irritation, and systemic toxicity) 8 days after receiving pristinamycin 3 g/day for 10 days [ 11 ]. An assay for Clostridium difficile was positive.