What is HER3 positive breast cancer?
HER3 is emerging as a crucial biomarker in luminal breast cancers. HER3 mRNA is expressed significantly in estrogen receptor positive (ER+) or luminal tumors, consistent with the observation that HER3 is essential for cell survival in the luminal but not the basal normal mammary epithelium.
What is HER4 breast cancer?
HER4 is known for its positive role in tumor progression, including the acceleration of human breast cancer cell growth [5, 6] and the induction of mouse mammary carcinoma formation .
What is the difference between HER2 and HER3?
The role of HER3 in HER2-driven breast cancers extends beyond its role in the genesis and growth of these tumors and accounts for much of the observed resistance to HER2 inhibitors. Unlike HER2, the expression of HER3 is highly dynamic and highly regulated11,12.
What is the survival rate of HER3 positive breast cancer?
Previous studies reported that HER3+ was associated with established prognostic indicators, such as higher histological grading  and primary breast tumors larger than 2 cm . Giltnane JM found that the high-HER3 group had a 53% 10-year survival compared to 69% in the low-HER3 group (P < 0.001) .
What is HER3 negative breast cancer?
What Is Triple-Negative Breast Cancer? Triple-negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer. One is a protein called human epidermal growth factor (HER2 ).
How is HER2-positive breast cancer treated?
HER2-directed therapy — Most women with HER2-positive breast cancer will receive one or more chemotherapy drugs plus trastuzumab, the anti-HER2 antibody. Many studies have shown that these treatments dramatically improve survival for women with HER2-positive breast cancer.
What is HER3 gene?
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
Is HER3 a kinase?
HER3 is a unique member of the HER family as it has been considered as an inactive receptor20, 21, although a recent study suggests that HER3 contains weak kinase activity22.
What is the survival rate of HER2 positive breast cancer?
But new treatments like chemotherapy plus trastuzumab have boosted early-stage HER2 positive breast cancer survival rates: 7-year disease-free: Around 93% 10-year disease-free: About 70%-75% Overall: 80%-85%
Is it better to be HER2-positive or triple negative?
Conclusions: The triple negative subtype has the worst survival regardless of stage. HER2-positive cancers are heterogeneous and not all have poor survival. ER and PR must be considered. ER status appears to influence 5-year survival more than HER2 status.
Is HER2-positive breast cancer a death sentence?
Current treatment algorithms for invasive HER2-positive disease has transformed the face of a disease with a death sentence to one with prolonged and overall survival benefit.