What is Aranesp injection used for?
Aranesp may be used to treat a lower than normal number of red blood cells (anemia) if it is caused by: • Chronic kidney disease (you may or may not be on dialysis). Chemotherapy that will be used for at least two months after starting Aranesp. months. If you have a cancer that has a high chance of being cured.
What is the half life of Aranesp?
Following IV administration to these patients, Aranesp™ serum concentration-time profiles are biphasic, with a distribution half-life of approximately 1.4 hours and the mean terminal half-life of 21 hours.
How long does Aranesp shot last?
How is Aranesp® typically given (administered)? Aranesp® may be given as a subcutaneous (under the skin) injection or rarely into a vein (intravenous). It is typically administered every two weeks, allowing patients to visit their doctor less frequently and avoid unnecessary injections.
Why does darbepoetin have a longer half-life?
Results: Due to its increased sialic acid-containing carbohydrate content, darbepoetin alfa has a higher molecular weight, a greater negative charge, and a approximately fourfold lower EPO receptor binding activity than rHuEPO. It also has a threefold longer circulating half-life than rHuEPO in rats and dogs.
Does Aranesp increase hemoglobin?
Aranesp Dosed Once Every Two Weeks Increases Hemoglobin Levels, Improves Fatigue And Reduces Need For Transfusions In Patients With Chemotherapy-Induced Anemia| Amgen.
How much does Aranesp cost without insurance?
About Aranesp It is used to treat anemia caused by chronic kidney failure and chemotherapy. The lowest GoodRx price for the most common version of Aranesp is around $759.98, 17% off the average retail price of $925.49.
How fast does Aranesp work?
Aranesp® “tells” the cells in your bone marrow to grow into new red blood cells within your bloodstream. Under healthy circumstances, it takes your body time to produce red blood cells (about 26 days 3,4,5,6). Increases in hemoglobin may not be observed until 2-6 weeks after you start taking Aranesp®.
How quickly does Aranesp work?
Does Aranesp stop working?
Rarely, Aranesp may suddenly stop working well after a period of time because your body may make antibodies that make it work less well, and serious anemia can result. Tell your doctor if symptoms of anemia return (such as increased tiredness, low energy, pale skin color, or shortness of breath).
How long does Aranesp take to work?
What is the half life of Epogen?
In adult and pediatric patients with CRF, the elimination half-life of plasma erythropoietin after intravenously administered EPOGEN® ranges from 4 to 13 hours. 13-15 The half-life is approximately 20% longer in CRF patients than that in healthy subjects.
Is Aranesp a biologic?
Aranesp is the trade name for darbepoetin alfa. In some cases, health care professionals may use the trade name aranesp when referring to the generic drug name darbepoetin alfa. Drug Type: Darbepoetin alfa is a biologic response modifier. It is an erythropoiesis stimulating protein.
Is Aranesp chemotherapy?
Indication. Aranesp® is indicated for the treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.
What is the dose strength of the Aranesp vial?
The dose strength of the Aranesp vial (number of micrograms [mcg] in the colored square on the package and on the vial label) is the same as your healthcare provider prescribed. The Aranesp liquid in the vial is clear and colorless.
What are the limitations of Aranesp?
Limitations of Use. Aranesp has not been shown to improve quality of life, fatigue, or patient well-being. Aranesp is not indicated for use: • In patients with cancer receiving hormonal agents, biologic products, or radiotherapy, unless also receiving concomitant myelosuppressive chemotherapy.
Is Aranesp safe for patients with high hemoglobin levels?
Using Aranesp to target a hemoglobin level of greater than 11 g/dL increases the risk of serious adverse cardiovascular reactions and has not been shown to provide additional benefit [see Clinical Studies ( 14.1 )]. Use caution in patients with coexistent cardiovascular disease and stroke [see Dosage and Administration ( 2.2 )].
How much Aranesp should I take for cancer treatment?
Use the lowest dose of Aranesp necessary to avoid RBC transfusions. Recommended Starting Dose. The recommended starting dose and schedules are: 2.25 mcg/kg every week subcutaneously until completion of a chemotherapy course. 500 mcg every 3 weeks subcutaneously until completion of a chemotherapy course.