What is an acinar pattern?
In the 2011 IASLC/ATS/ERS classification of lung adenocarcinoma, acinar pattern is defined as glandular structures that are round to oval shaped, with a central luminal space surrounded by tumor cells; cribriform arrangements are also regarded as a pattern of acinar adenocarcinoma.
What is acinar predominant?
Acinar-predominant adenocarcinoma of the lung is a histological subtype of non-mucinous invasive adenocarcinoma of the lung.
What is ttf1 positive?
TTF-1 is a lineage marker and has been used as a diagnostic marker for lung adenocarcinoma and small cell carcinoma [7]. A subsequent study showed that TTF-1 overexpression was a favorable prognostic marker among patients with lung adenocarcinoma [8].
What is Lepidic growth?
Lepidic growth adenocarcinoma is defined as tumor cells proliferating along the surface of intact alveolar walls without stromal or vascular invasion pathologically (1). The traditional viewpoint has been that of Noguchi et al.
Where are acinar cells?
The pancreatic acinar cell is the functional unit of the exocrine pancreas. It synthesizes, stores, and secretes digestive enzymes. Under normal physiological conditions, digestive enzymes are activated only once they have reached the duodenum.
What is a acinus lung?
A pulmonary acinus is usually defined as the region of lung supplied by a first-order respiratory bronchiole and includes the respiratory bronchioles, alveolar ducts and alveolar sacs distal to a single terminal bronchiole (Fig. 1.6).
What are acini cells?
Acinar cells are located in the pancreas, and they make, store, and secrete digestive enzymes (proteins that help biochemical reactions in the body occur) in the form of pancreatic fluids.
What is acinar adenocarcinoma?
Acinar adenocarcinoma is a histological subtype of gland-forming cancer that is diagnosed when cuboidal and/or columnar shaped malignant cells in the neoplastic tissue form acini and tubules. It is a common form of cancer occurring in the lung and prostate gland.
What is the role of acinar cells?
The acinar cell is the workhorse of the exocrine pancreas—its primary responsibility is the production, storage and regulated secretion of the large amounts of enzymes necessary for the proper digestion and absorption of food.
What’s the function of the acinar cells?
Pancreatic acinar cells synthesize and secrete almost all the digestive enzymes active in the lumen of the small intestine which are necessary for nutrient digestion. Both synthesis and secretion are highly regulated over both short and long time frames to insure an appropriate supply of digestive enzymes.
Is acinar and alveolar the same?
cells in rounded sacs, called acini, attached to freely branching systems of ducts. The walls of the acini surround a small central cavity known as an alveolus. In the walls of the acini are pyramidal secreting cells and some flat, star-shaped contractile cells called myoepithelial, or basket, cells. The latter…
What are acinar ducts?
human digestive system Individual acinar cells have the shape of a truncated pyramid, arranged in groups around a central ductal lumen. These central ducts empty into progressively larger intercalated and collecting ducts that eventually join the pancreatic duct (duct of Wirsung).
What is acinar tissue?
Acinar Tissue They are pyramidal cells that radiate around small offshoots of the pancreatic duct. The pancreatic duct extends throughout the entire length of the pancreas and its epithelial cell lining produces bicarbonate to neutralize and protect the pancreas from its secretions.
How do you identify acinar cells?
Acinar cells are pyramidal, are oriented radially around a tiny, central lumen, and have intracytoplasmic, membrane-bound zymogen granules in the apical region. The more basophilic perinuclear region, containing the rough endoplasmic reticulum, gives the acinar cell a two-toned, apical–basal polarized appearance.
What is TTF-1 a marker for?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas.
What is adenocarcinoma in situ?
A condition in which abnormal cells are found in the glandular tissue, which lines certain internal organs and makes and releases substances in the body, such as mucus, digestive juices, and other fluids. These abnormal cells may become cancer and spread into nearby normal tissue.
What is the reticular pattern on a CT scan?
(See also reticular pattern.) On CT scans, the pattern appears as a concurrence of reticular and micronodular patterns. The micronodules can be situated in the center of the reticular elements (e.g., centrilobular micronodules) or superimposed on the linear opacities (e.g., septal micronodules).
How does the new classification of adenocarcinoma affect radiologic interpretation?
This new classification especially affects radiologic interpretation of computed tomographic (CT) scans for the diagnosis of adenocarcinoma, including those tumors detected at CT screening. These new aspects are the subject of this review.
What is an acinar nodule in pulmonary opacities?
(a) Acinar nodules are round or ovoid poorly defined pulmonary opacities approximately 5–8 mm in diameter, presumed to represent an atomic acinus rendered opaque by consolidation. This classification is used only in the presence of numerous such opacities.
What is acinar emphysema on CT scan?
and 67. CT. – This emphysema is characterized by subpleural and peribronchovascular regions of low attenuation separated by intact interlobular septa ( Fig. 47 ), sometimes associated with bullae. The term distal acinar emphysema is synonymous. (See also emphysema.) Anatomy.