What is agmatine used for?
Agmatine is a chemical found in bacteria, plants, and animals, including humans. It is made from the amino acid known as arginine. Agmatine is commonly used by mouth for depression, nerve pain, improving athletic performance, and many more conditions.
Does agmatine cross the blood-brain barrier?
The ventricular injection of agmatine resulted in a threefold sustained rise in blood plasma agmatine for at least 24 hours after injection. Therefore, agmatine and its precursor, arginine, cross the blood-brain barrier.
Is agmatine a drug?
Agmatine is both an experimental and investigational drug. As an investigational drug, it is being studied in a non-blinded prospective case study in the United States looking at patients who have been diagnosed with small fiber peripheral neuropathy between the ages of 18 to 75 years.
How long does agmatine stay in your system?
Oral agmatine is absorbed from the gastrointestinal tract and readily distributed throughout the body. Rapid elimination from non-brain organs of ingested (un-metabolized) agmatine by the kidneys has indicated a blood half life of about 2 hours.
Does agmatine help you sleep?
I take this to help sleep. Specifically I’ll take one in the predawn hour when I nearly always wake up at least once, and it seems to help me get back to sleep very solidly for the last hour or two. It’s almost like it anchors me down in deep sleep and I wake up feeling like the sleep did its job better.
What is agmatine?
?) Agmatine, also known as (4-aminobutyl)guanidine, is an aminoguanidine that was discovered in 1910 by Albrecht Kossel. Agmatine is a chemical substance which is naturally created from the amino acid arginine.
Why is agmatine used as a surrogate metric of ionic flux?
Due to its ability to pass through open cationic channels, agmatine has also been used as a surrogate metric of integrated ionic flux into neural tissue upon stimulation.
How much agmatine should I take?
Stay within current recommended dosage limits of around 500mg per day until more information comes to light. Agmatine is one of the more exciting supplements on the way up in the industry today. There are at least 3 clear benefits to cognitive function, pain reduction and physical performance.
What is the concentration of agmatine in human serum?
Serum concentrations of agmatine have been detected in the ranges of 6.8+/-0.6ng/mL and 6.8-16.9ng/mL in rats, but appear to be significantly higher in humans such as 47ng/mL, 33.8+/-16.6ng/mL, or 79.42-82.44ng/mL.