What functional groups are in lidocaine?
Lidocaine is a drug used as an anesthetic and for the treatment of chronic pain, which bears in its chemical structure an amide functional group able to form hydrogen bonds.
What is the chemical structure of lidocaine?
Lidocaine | C14H22N2O – PubChem.
What is the function of lidocaine?
LIDOCAINE (LYE doe kane) is an anesthetic. It causes loss of feeling in the skin and surrounding tissues. It is used to prevent and to treat pain from some procedures. This medicine is also used to treat minor burns, scrapes and insect bites.
What is lidocaine made of?
First synthesized between 1943 and 1946 by Nils Löfgren and Bengt Lundquist, it is a tertiary amine derived from xylidine, and its use rapidly became widespread given its superior safety profile compared to older local anesthetic agents.
Is lidocaine an amide?
The commonly used amide LAs include lidocaine, bupivacaine, ropivacaine, mepivacaine, and outside the United States, levobupivacaine. Articaine is an amide LA used primarily in dentistry. LAs are weak bases that exist in solution in both charged and uncharged forms.
How do you use lidocaine gel?
Apply a small amount of Lidocaine gel to the affected area. Gently rub the medicine in until it is evenly distributed. If applying to broken skin, use a sterile gauze pad to apply the medicine. Wash your hands immediately after using Lidocaine gel unless your hands are part of the treated area.
What are other names for lidocaine?
Lidocaine is available under the following different brand names: Lidocaine CV, and Lidopen.
Is lidocaine an amide or ester?
Commonly used ester LAs include chloroprocaine, procaine, and tetracaine. The commonly used amide LAs include lidocaine, bupivacaine, ropivacaine, mepivacaine, and outside the United States, levobupivacaine. Articaine is an amide LA used primarily in dentistry.
What is lidocaine cream?
About lidocaine skin cream Lidocaine is a local anaesthetic. Using the skin cream makes your skin numb. You can use it before having blood taken or having a drip put in. Your doctor or nurse may also tell you to use it before having a small surgical procedure. Lidocaine skin cream is available on prescription.
Is lidocaine an amine?
Amino-amides (lidocaine, mepivacaine, prilocaine, ropivacaine, bupivacaine and etidocaine) have an amide link between the aromatic end and the intermediate chain.
What are the two groups of local anesthetics?
Two basic classes of local anesthetics exist, the amino amides and the amino esters. Amino amides have an amide link between the intermediate chain and the aromatic end, whereas amino esters have an ester link between the intermediate chain and the aromatic end. Amino esters and amino amides differ in several respects.
What is lignocaine gel 2 used for?
Lignocaine 2% Gel is an anaesthetic gel used as a lubricant for the insertion of instruments for medical procedures, such as catheters, and for the treatment of symptoms of painful inflammation of the urethra and bladder.
What is the structure of lidocaine?
In order to answer this question we will first need to look at the structure of lidocaine. Lidocaine, or 2- (diethylamino)-N- (2,6-dimethyl phenyl)-acetamide, is an amide, which means it contains an amine bond like with amino acids. This amide has a NH (nitrogen-hydrogen) bound to a CO (carbon-oxygen, double bond).
Is lidocaine a benzene or amide?
Lidocaine, or 2- (diethylamino)-N- (2,6-dimethyl phenyl)-acetamide, is an amide, which means it contains an amine bond with amino acids. This amide is an NH (nitrogen-hydrogen) bound to a CO (carbon-oxygen, double bond). On the other side of the NH group is a benzene with two methyl groups on both of the ortho positions.
What is lidocaine used for?
One last thing worth mentioning is that lidocaine can also act as an antiarrhythmic drug, meaning one used to help treat abnormal heart rhythms. The mechanism of action as an antiarrhythmic is exactly the same as a local anesthetic. Arrhythmia can occur when action potentials are formed from voltages caused by the voltage-gated channels.
How does lidocaine work as an antiarrhythmic?
Lidocaine can also act as an antiarrhythmic drug (one used to help treat abnormal heart rhythms). The mechanism of action as an antiarrhythmic is exactly the same as a local anesthetic. Arrhythmia can occur when action potentials are formed from voltages caused by the voltage-gated channels.