How are antibiotics dosed for obesity?
Using this data in simulations, one study found low PTA with 2 g IV every 12 hour dosing, leading the authors to recommend 2 g every 8 hour dosing in morbidly obese patients (Table S2).
How should anesthetics be dosed in obese patients?
In general, lean body weight is the most appropriate dose for most anesthetic drugs, with the exception of NDMB, where ideal body weight may be more appropriate. Succinylcholine should be dosed to total body weight.
How often can teicoplanin be given?
One single dose of 6-10 mg/kg body weight administered intravenously once a day. Teicoplanin should be administered by the intravenous or intramuscular route. The intravenous injection may be administered either as a bolus over 3 to 5 minutes or as a 30-minute infusion.
Is vancomycin dosing based on ideal body weight?
Current guidelines for systemic vancomycin dosing and monitoring recommend calculating initial doses (15–20 mg/kg every 8–12 hours) using actual body weight (ABW), regardless of BMI, followed by therapeutic drug monitoring for dose adjustments .
Should Antibiotics be dosed by weight?
Treatment of severe infections and patients with serious medical problems may require personalized dosing. But for the routine infections that constitute the bulk of office-based practice — such as urinary tract infections, sinusitis and bronchitis — one dose is generally reasonable regardless of body weight.
Are antibiotics dosed by weight?
Whereas children’s antibiotic dosing is generally calculated according to body mass, for adults, no such system is in place, and for those drugs that do have body mass specific guidelines for dosing, adherence is “inadequate,” according to the authors. Drs. Matthew E.
Is there a weight limit for anesthesia?
There is no weight limit for surgery, per se. If one needs life-saving surgery, surgery will be done independently of a patient’s weight. However, being obese or morbidly obese increases the risk for complications from anesthesia and surgery alike, especially in an emergent situation.
Should dosing of rocuronium in obese patients be based on ideal or corrected body weight?
Background: Pharmacokinetic studies in obese patients suggest that dosing of rocuronium should be based on ideal body weight (IBW).
Is teicoplanin nephrotoxic?
Teicoplanin is nephrotoxic in animals, although at much higher doses than those used in humans. This antibiotic also appears to have less nephrotoxic synergism with aminoglycosides than vancomycin.
When should teicoplanin levels be taken?
Take a trough level (just before the next scheduled dose) on Day 5. Samples must NOT be taken via lines. Teicoplanin dose adjustments should not be made until the pre-dose trough level is reported. Samples are sent to a regional reference centre and it may take a few days to come back.
How does obesity affect vancomycin?
In addition to an increase in body mass, obesity is associated with an increase in certain circulating proteins, which results in altered free serum vancomycin concentration.
What is the IBW formula?
Formulas for calculating ideal body weight You are considered obese if you 30% more than your IBW. A common formula is as follows: Men: IBW (kgs) = 22 × (height in meters)2. Women: IBW (kgs) = 22 × (height in meters − 10 cm)2.
How much teicoplanin should I take if I am obese?
There is no dose adjustment required for the dosing of teicoplanin in obese patients. Ideal body weight should always be used to calculate creatinine clearance using the Cockroft & Gault method for patients who are obese. Note dose should be capped at a maximum of 2gram as a single dose. This guideline is not for use in paediatrics.
How is teicoplanin administered?
Teicoplanin can be administered intramuscularly and intravenously for a systemic infection (as a bolus for doses ≤800mg or as an infusion for doses >800mg.) In rare cases (even at the first dose), red man syndrome has been observed. Stopping or slowing the infusion may result in cessation of these reactions.
Why can’t patients on dialysis take teicoplanin 72 hour dosing?
Patients receiving dialysis at Leeds are not suitable for 72 hour dosing due to the increased clearance of teicoplanin in HDF / Hi-Flux dialysis therefore resulting in subtherapeutic drug levels when dialysis and teicoplanin dosing times do not coincide.
How do I report adverse reactions to teicoplanin?
Any suspected adverse reactions should be reporte via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. The Outpatient Parenteral Antimicrobial Therapy (OPAT) service can support with discharging patients requiring teicoplanin. Please refer to the OPAT/CIVAS team.