Why is it called pseudoexfoliation?
It is called ‘pseudoexfoliation’ to differentiate it from true exfoliation which is due to heat or infrared related changes in anterior lens capsule.
How does pseudoexfoliation affect cataract surgery?
“Pseudoexfoliation patients don’t dilate as well as other patients do,” notes Dr. Devgan. “Notably, it turns out that the ones who are dilating more poorly tend to have weaker zonular support during surgery, while the pseudoexfoliation patients who dilate better tend to have somewhat better zonular support.”
How does pseudoexfoliation occur?
This is thought to be a result of oxidative stress. The material is then released into the extracellular space and deposited around the cells that produced the material, and also other structures such as the zonules, pupillary margin and anterior lens surface.
Is pseudoexfoliation serious?
Pseudoexfoliation glaucoma (PEG) is a common cause of blindness worldwide and tends to be more progressive and serious compared to primary OAG (POAG).
What is Pseudoexfoliation syndrome of the eye?
Pseudoexfoliation syndrome (PXF or PEX) is an age-related systemic syndrome that targets mainly ocular tissues through the gradual deposition of fibrillary white flaky material from the lens, mainly on the lens capsule, ciliary body, zonules, corneal endothelium, iris and pupillary margin.
How common is Pseudoexfoliation syndrome?
It is more common in women than in men. There is a high prevalence of pseudoexfoliation syndrome in Scandinavian countries, where it is estimated that 50 percent of open-angle glaucoma is caused by pseudoexfoliation syndrome. On the other hand, it is relatively rare among African Americans and Eskimos.
What is pseudoexfoliation in ophthalmology?
Is pseudoexfoliation glaucoma hereditary?
Pseudoexfoliation syndrome is a major cause of glaucoma that has a strong familial association. Recent studies have confirmed that LOXL1 is a major gene associated with both XFS and XFG.
How is pseudoexfoliation treated?
Glaucoma Treatments: Immediate treatment for early-stage, open-angle glaucoma can delay progression of the disease. That’s why early diagnosis is very important. Glaucoma treatments include eye drops, laser trabeculoplasty, conventional surgery, or a combination of any of these.
What is Pseudoexfoliation syndrome?
Is there a cure for pseudoexfoliation?
Pseudoexfoliation is the most common cause of secondary glaucoma worldwide and can be difficult to treat. MicroPulse laser trabeculoplasty is an effective treatment that is safe and can be repeated as necessary.
Does pseudoexfoliation always lead to glaucoma?
If you have pseudoexfoliation syndrome, does that mean you will develop glaucoma? Although there are patients in whom pseudoexfoliation material is seen but there is no sign of glaucoma, it is estimated that approximately 40 – 50 percent of patients who have pseudoexfoliation syndrome will eventually develop glaucoma.
In 1971, a Finnish ophthalmologist John Linberg is the first doctor who described Pseudoexfoliation syndrome. He reported the classic findings of white/grey flakes on the anterior lens capsule, glaucoma in approximately 50% of eyes, and an increasing prevalence of the condition with advancement of the age.
What is Pseudoexfoliation syndrome (LOXL1)?
The gene is called LOXL1 Because pseudoexfoliation syndrome is associated with abnormalities of the extracellular matrix and the basement membrane, this gene could reasonably play a role in the pathophysiology of the condition.
What is the gene for pseudoexfoliation?
Known Genes or Gene Locus: LOXL1. Exfoliation or pseudoexfoliation syndrome (PXF) is an age-related ocular and systemic disease in which abnormal extracellular material is produced and accumulates in many tissues. PXF is the most common identifiable cause of open-angle glaucoma (OAG).
What is the pathophysiology of zone zonular weakness?
Zonular weakness can be attributed to the deposition of pseudoexfoliative material on the zonular fibers and ciliary processes, resulting in a proteolytic disintegration of the zonule that can lead to spontaneous fragmentation.